Biological Evaluation of Natural Antioxidants from Residual Sources

This work has been carried out to evaluate biologically the safety utilization of the byproducts, namely orange peel and permeate and investigate the antioxidant role of them against the oxidative stress in lipid peroxidation induced in adult albino rats by the oral ingestion of CCL . The lipid profile namely total 4 cholesterol, HDL, LDL and triglycerides were performed and the results indicated that the reactive oxygen (RO) and oxidative stress associated with ccl induced hepatotoxicity. In this case the lipid peroxidation level was 4 induced in liver by the increase of MDA level in hepatotoxicity rats after 4 and 8 weeks. The obtained data revealed the safety utilization of both orange peel and permeate. The data also showed the prophylactic effect of reconstituted orange peel and permeate on ccl induced hepatotoxicity treatment after zero, 4 and 8 weeks 4 time intervals. On the other hand after treatment by preoral ingestion of both orange peel and permeate for 8 weeks, the data exerted a prophylactic effect against the oxidative stress caused by CCL as indicated by the 4 recovery in the levels of lipid profile and MDA. In addition, histopathological study was performed, similar trend of results were corresponding to the biochemical parameters.